Polyethylene microplastics transported to nucleus pulposus cells via macrophages-derived exosomes, and promote intervertebral disc degeneration through NAT10/SLC7A11 and ac4C modification
PE-MPs could be transported to NPCs via M0-MPs-exo, and trigger lipid peroxidation and ferroptosis through regulating NAT10/SLC7A11 and ac4C modification, thereby promoting IVDD.
Authors
- Wei Zhao (ORCID: https://orcid.org/0000-0002-5591-5676)
- Kuize Liu
- Yen Wei (ORCID: https://orcid.org/0000-0001-5950-0163)
- David Jui-Yang Feng (ORCID: https://orcid.org/0000-0001-5841-2225)
- Bo Zhou (ORCID: https://orcid.org/0000-0001-8821-8757)
- Zhencong Li (ORCID: https://orcid.org/0009-0003-9264-7361)
- Siyuan Chen (ORCID: https://orcid.org/0009-0001-8475-0305)
- Weilin Zhang (ORCID: https://orcid.org/0000-0001-8618-8144)
- Zhiwen Dai
- Jinsong Wei (ORCID: https://orcid.org/0000-0002-2822-356X)
- Shengbang Huang
- Jinguo Liang
Institutions
- Guangdong Medical College (CN)
- North Minzu University (CN)
- Fourth Affiliated Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119324
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47