Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Acute Exercise (flADex): Protocol for a Randomized Crossover Trial
flADex will highlight the acute effects of different exercise types on CBF and biomarkers before beta-amyloid accumulation. Acute effects on CBF dynamics and blood biomarkers are expected to be greater with aerobic than resistance exercise when compared to resting. CBF is expected to vary by brain region, and biomarkers to fluctuate dynamically postexercise. This will provide critical insights into exercise's impact on vascular and molecular pathways associated with AD pathology and potential recommendations for standardized blood sampling to enhance diagnostic accuracy.
Authors
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- Manuel María Gómez-Río
- Marcos Olvera‐Rojas (ORCID: https://orcid.org/0000-0001-7922-1647)
- Darío Bellón (ORCID: https://orcid.org/0009-0008-7289-8776)
- Patricio Solis‐Urra (ORCID: https://orcid.org/0000-0002-2493-9528)
- Javier Sanchez‐Martinez (ORCID: https://orcid.org/0000-0002-9451-8454)
- Esmée A. Bakker (ORCID: https://orcid.org/0000-0003-3899-471X)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Irene Esteban‐Cornejo (ORCID: https://orcid.org/0000-0002-0027-1770)
- Francisco B. Ortega (ORCID: https://orcid.org/0000-0003-2001-1121)
- Sol Vidal‐Almela (ORCID: https://orcid.org/0000-0003-4491-0826)
- Isabel Martín‐Fuentes (ORCID: https://orcid.org/0000-0003-4268-1935)
- Ángel Toval (ORCID: https://orcid.org/0000-0003-4798-1216)
- Alessandro Sclafani (ORCID: https://orcid.org/0009-0008-6573-6867)
- Beatriz Fernandez‐Gamez (ORCID: https://orcid.org/0000-0002-8987-9925)
- Lucía Sánchez‐Aranda (ORCID: https://orcid.org/0009-0001-0234-8751)
- Emilio J. Barranco‐Moreno (ORCID: https://orcid.org/0009-0006-1168-1931)
- Alfredo Caro‐Rus
- Javier Fernández‐Ortega (ORCID: https://orcid.org/0000-0002-9236-9504)
- Andrea Coca‐Pulido (ORCID: https://orcid.org/0009-0008-1249-6353)
- Jose D. Marin‐Alvarez
Institutions
- Radboud University Nijmegen (NL)
- University of Pittsburgh (US)
- Universidad de Granada (ES)
- Instituto de Salud Carlos III (ES)
- Radboud University Medical Center (NL)
- Viña del Mar University (CL)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- University of Gothenburg (SE)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1002/brb3.70636
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agenția Națională pentru Cercetare și Dezvoltare
- European Commission
- Agencia Nacional de Investigación y Desarrollo
- European Regional Development Fund
- Agencia Estatal de Investigación
- European Social Fund
- CHIST-ERA