Heart failure diagnosis: Impacts of atrial fibrillation on the diagnostic marker NT-proBNP
A recent PLOS Medicine study shows that atrial fibrillation lowers the specificity of the biomarker NT-proBNP for heart failure. Adjusted thresholds and better echocardiography access are therefore required for NT-proBNP to remain as a high negative predictive value rule-out test in primary care.
Authors
- Gregory Y.H. Lip (ORCID: https://orcid.org/0000-0002-7566-1626)
- Garry McDowell (ORCID: https://orcid.org/0000-0002-2880-5236)
- Yang Chen (ORCID: https://orcid.org/0000-0002-2808-6286)
Institutions
- Medical University of Białystok (PL)
- University of Liverpool (GB)
- Liverpool Heart and Chest Hospital (GB)
- Liverpool John Moores University (GB)
- Aalborg University (DK)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1371/journal.pmed.1004782
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00