Lipoprotein(a) prolongs ex vivo plasma clot lysis times through effects on clot formation rate and fibrin structure
The strong antifibrinolytic effects of apo(a) do not appear to be retained in the complete Lp(a) particle. However, Lp(a) and apo(a) displayed procoagulant effects, in part dependent on the kringle 4-like lysine-binding site. Further analysis is required to determine whether these reported procoagulant effects of Lp(a) impact thrombosis in vivo.
Authors
- Michael B. Boffa (ORCID: https://orcid.org/0000-0003-1211-3064)
- Justin R. Clark (ORCID: https://orcid.org/0000-0003-1590-6828)
- Robert Szabla (ORCID: https://orcid.org/0000-0002-6379-232X)
- Marlys L. Koschinsky (ORCID: https://orcid.org/0000-0002-2643-2288)
- M.S. Junop (ORCID: https://orcid.org/0000-0001-6676-5717)
- Julia M. Assini
- Frances S. K. Sutherland
- Luke Daichedt
Institutions
- Western University (CA)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.jtha.2025.10.009
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01