Association between pre-diagnostic fluoroquinolone exposure and possible acquired fluoroquinolone resistance in Mycobacterium tuberculosis in Shanghai: An EHR-based case-control study using whole-genome sequencing
Acquired resistance dominates FQ resistance in Shanghai TB patients. The dose-response relationship between pre-diagnostic FQ exposure and possible acquired resistance underscores the need for judicious FQ use.
Authors
- Xin Shen (ORCID: https://orcid.org/0000-0003-4686-2215)
- Jiazhen Liu
- Danni Li (ORCID: https://orcid.org/0009-0007-5595-9138)
- Yangyi Zhang (ORCID: https://orcid.org/0000-0002-5465-6334)
- Yuan Jiang (ORCID: https://orcid.org/0000-0003-1211-6812)
- Biao Xu (ORCID: https://orcid.org/0000-0001-5390-2583)
Institutions
- Shanghai Medical Information Center (CN)
- Shanghai Public Health Clinical Center (CN)
- Shanghai Municipal Center For Disease Control Prevention (CN)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.jinf.2025.106648
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China