A Novel Relationship between Corticotropin-Releasing Hormone Level and High-Altitude Hypoxia in Human and Rat Model
Hypobaric hypoxia is associated with high plasma CRH in rats. In humans, strong activation of CRH and CRHR1 is positively linked to AMS. CRH levels in saliva or plasma appear to predict individual responses to hypoxia.
Authors
- Ke Hao (ORCID: https://orcid.org/0000-0002-1815-9197)
- Nicholas C. Spitzer (ORCID: https://orcid.org/0000-0002-3523-1103)
- Songchao Chen (ORCID: https://orcid.org/0000-0003-1245-0482)
- Feng‐Ming Kong (ORCID: https://orcid.org/0000-0003-2652-098X)
- Gang Xu (ORCID: https://orcid.org/0000-0001-5505-5939)
- Yang Zhao (ORCID: https://orcid.org/0000-0002-8703-3678)
- Jian Wang (ORCID: https://orcid.org/0000-0003-3633-6799)
- Yu Qi Gao
- Jun Lin (ORCID: https://orcid.org/0000-0003-4836-4746)
- Xue Qun Chen (ORCID: https://orcid.org/0000-0002-6105-8869)
- John H. Coote
- Ping Ping Wang
- Ji Du (ORCID: https://orcid.org/0009-0001-9388-8146)
- Jian Chen (ORCID: https://orcid.org/0000-0002-7219-4938)
Institutions
- NSF NCAR High Altitude Observatory (US)
- Army Medical University (CN)
- Ministry of Education (SA)
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- University of Birmingham (GB)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1159/000549191
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Peking University
- National Key Research and Development Program of China