Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology
The number of elastic lamellae in the aortic wall is influenced by both age and valve morphology. BAV patients had less lamellae than TAV patients, which could contribute to the disparity in clinical outcomes. In older adults, age-related lamellar degeneration likely increases the risk of aortopathy.
Authors
- Robert E. Poelmann (ORCID: https://orcid.org/0000-0002-9684-3007)
- Nimrat Grewal (ORCID: https://orcid.org/0000-0001-9981-8336)
- Mohammad Ali Zafar (ORCID: https://orcid.org/0000-0003-1666-199X)
- Robert J.M. Klautz (ORCID: https://orcid.org/0000-0002-6507-3855)
- John Alex Elefteriades (ORCID: https://orcid.org/0000-0001-6255-8139)
- Nicole Kargin
- Nora Bacour (ORCID: https://orcid.org/0009-0000-6926-9890)
- Bulat Zinganshin
Institutions
- Leiden University (NL)
- Yale New Haven Hospital (US)
- Leiden University Medical Center (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Cardiovascular Pathology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.carpath.2025.107789
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39