Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel kinetics modulation
In summary, substrate stiffening impaired cardiomyocyte depolarization and promoted conduction abnormalities via Nav1.5 dysfunction, suggesting a mechanoelectrical mechanism in ECM deposition related arrhythmogenesis.
Authors
- Sheng‐an Su
- Meixiang Xiang (ORCID: https://orcid.org/0000-0003-0255-6056)
- Yutao Xi (ORCID: https://orcid.org/0000-0002-2537-2527)
- Yuan Zhu
- Jixie Le
Institutions
- Valve (United States) (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Archives of Biochemistry and Biophysics
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.abb.2025.110668
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00