The <scp>LGALS9</scp> / <scp>miR</scp> ‐491‐5p Axis Regulates <scp>CD8</scp> <sup>+</sup> T Cell Function and Inhibits the Progression of Gastric Cancer
Gastric cancer is a prevalent and clinically significant gastrointestinal malignancy worldwide. Gastric cancer is characterized by limited treatment efficacy and a high recurrence rate. In this study, we found that LGALS9 was highly expressed in gastric cancer and may contribute to disease progression by modulating the infiltration of CD8<sup>+</sup> T cells. Genetic knockout of LGALS9 reversed T cell function, attenuated immunosuppression, and enhanced the cytotoxic activity of T cells to kill gastric cancer cells. Furthermore, miR-491-5p was identified as a potential suppressor in gastric cancer. The microRNA miR-491-5p regulated T cell-mediated immunity by targeting and inhibiting LGALS9, which was similar to the effect of LGALS9 knockout. Overall, the key target LGALS9 and its inhibitor miR-491-5p represent promising potential for treating gastric cancer.
Authors
- Yingli Zhou (ORCID: https://orcid.org/0000-0002-3757-0029)
- Honghong Fan
- Wan-Hong Huang (ORCID: https://orcid.org/0000-0003-3930-8523)
- Tao Hong (ORCID: https://orcid.org/0000-0001-8349-7793)
- Wenjuan Li (ORCID: https://orcid.org/0000-0003-1898-6448)
- Dagao Zhu
- Chen Liu (ORCID: https://orcid.org/0000-0002-9532-7721)
- Wei Lü (ORCID: https://orcid.org/0000-0003-4159-3861)
- Liangliang Li (ORCID: https://orcid.org/0000-0002-0078-6280)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-4291-6642)
- Jun Tao (ORCID: https://orcid.org/0000-0002-5052-5898)
- Zhi Sun (ORCID: https://orcid.org/0009-0000-6893-7316)
Institutions
- University of Science and Technology of China (CN)
- The People's Hospital Tongling (CN)
- Anhui Provincial Hospital (CN)
- Tongling University (CN)
Publication Details
- Journal
- Cancer Science
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1111/cas.70232
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bengbu Medical College