Prognostic Role of Breast Architecture in Imaging, Histopathology, and Breast Cancer Outcome

<b>Aims.</b> This study investigates the prognostic significance of mammographic density in breast cancer detection, histopathological patterns, treatment outcomes, and the diagnostic efficacy of different imaging modalities.<br /> <b>Methods.</b> A retrospective analysis was conducted using data from approximately 7,000 women (20% of the annual screening cohort of 35,000) over the 10-year period. Breast density was classified using BI-RADS categories (A–D). The frequency of breast cancer detection in each density category was analyzed. Imaging methods included mammography, ultrasound, and MRI. Recommendations for women with high-density breasts were developed based on findings.<br /> <b>Results.</b> High breast density (BI-RADS C and D) was identified in approximately 60% of screened women. Breast cancer detection rates were significantly higher in BI-RADS C (55%) and BI-RADS D (60%) groups compared to BI-RADS A (12%) and BI-RADS B (15%). Tumor sizes were larger in high-density breasts (2.5 cm for BI-RADS C, 2.8 cm for BI-RADS D). Mammography sensitivity decreased in dense breasts, whereas ultrasound and MRI showed higher sensitivity (90–97%). Based on these findings, guidelines for women with high-density breasts were proposed, emphasizing supplemental imaging and personalized screening.<br /> <b>Conclusion.</b> High mammographic density is associated with aggressive tumour types, larger tumour sizes, and poorer outcomes.<br /> <b>Aims.</b> This study investigates the prognostic significance of mammographic density in breast cancer detection, histopathological patterns, treatment outcomes, and the diagnostic efficacy of different imaging modalities.<br /> <b>Methods.</b> A retrospective analysis was conducted using data from approximately 7,000 women (20% of the annual screening cohort of 35,000) over the 10-year period. Breast density was classified using BI-RADS categories (A–D). The frequency of breast cancer detection in each density category was analyzed. Imaging methods included mammography, ultrasound, and MRI. Recommendations for women with high-density breasts were developed based on findings.<br /> <b>Results.</b> High breast density (BI-RADS C and D) was identified in approximately 60% of screened women. Breast cancer detection rates were significantly higher in BI-RADS C (55%) and BI-RADS D (60%) groups compared to BI-RADS A (12%) and BI-RADS B (15%). Tumor sizes were larger in high-density breasts (2.5 cm for BI-RADS C, 2.8 cm for BI-RADS D). Mammography sensitivity decreased in dense breasts, whereas ultrasound and MRI showed higher sensitivity (90–97%). Based on these findings, guidelines for women with high-density breasts were proposed, emphasizing supplemental imaging and personalized screening.<br /> <b>Conclusion.</b> High mammographic density is associated with aggressive tumour types, larger tumour sizes, and poorer outcomes.