Real-World Off-Label Use of Semaglutide for Weight Reduction: User Behavior, Effectiveness, and Satisfaction

Off-label Ozempic use in Arab populations is characterized by widespread self-initiation, irregular dosing, and early discontinuation. Nonetheless, clinically meaningful weight loss was achieved in many users. These findings emphasize the need for structured counseling to optimize outcomes.

Authors

Ayman M. Al‐Qaaneh (ORCID: https://orcid.org/0000-0002-6342-6573)
Eyad Qunaibi (ORCID: https://orcid.org/0000-0003-0648-0757)
Natalia A Al-Fraihat
Baraa E Abu-Aisheh
Sameh Rabea
Adnan A Al Aloul
Rajaa Matahen
Firas Annabi

Institutions

Alfaisal University (SA)
Hashemite University (JO)
Water Authority of Jordan (JO)
Al-Balqa Applied University (JO)
Riyadh Elm University (SA)
TQ Pharma (Jordan) (JO)
Islamic Hospital (JO)
Bioterra University Bucharest (RO)
King Abdullah Medical City (SA)

Publication Details

Journal: Patient Preference and Adherence
Published: 2025-10-31
DOI: https://doi.org/10.2147/ppa.s549716
Primary Topic: Diabetes Treatment and Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Real-World Off-Label Use of Semaglutide for Weight Reduction: User Behavior, Effectiveness, and Satisfaction

Ayman M. Al‐Qaaneh, Eyad Qunaibi, Natalia A Al-Fraihat, Baraa E Abu-Aisheh et al.

Oct 31, 2025

Patient Preference and Adherence

Diabetes Treatment and Management

article

Real-World Off-Label Use of Semaglutide for Weight Reduction: User Behavior, Effectiveness, and Satisfaction

Ayman M. Al‐Qaaneh, Eyad Qunaibi, Natalia A Al-Fraihat, Baraa E Abu-Aisheh, Sameh Rabea, Adnan A Al Aloul, Rajaa Matahen, Firas Annabi

October 31, 2025article en

Abstract

Off-label Ozempic use in Arab populations is characterized by widespread self-initiation, irregular dosing, and early discontinuation. Nonetheless, clinically meaningful weight loss was achieved in many users. These findings emphasize the need for structured counseling to optimize outcomes.

Patient Preference and AdherenceVol. Volume 19

Alfaisal University (SA), Hashemite University (JO), Water Authority of Jordan (JO), Al-Balqa Applied University (JO), Riyadh Elm University (SA), TQ Pharma (Jordan) (JO), Islamic Hospital (JO), Bioterra University Bucharest (RO), King Abdullah Medical City (SA)

Openalex Percentile: Top 57%

Diabetes Treatment and Management

DOI Open Access PDF OpenAlex

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Real-World Off-Label Use of Semaglutide for Weight Reduction: User Behavior, Effectiveness, and Satisfaction — Ayman M. Al‐Qaaneh, Eyad Qunaibi, et al. · Patient Preference and Adherence (2025) | TGRS Research Map | TGRS