β-Lactam vs Non–β-Lactam Antimicrobial Prophylaxis and Surgical Site Infection
In this large cohort study, administration of non-β-lactam SAP was associated with 1.8-fold higher odds of SSI. These findings suggest that non-β-lactam SAP should be avoided whenever possible. A careful evaluation of patients with reported β-lactam allergy should be performed before administering a second-choice antibiotic.
Authors
- Laurence Senn (ORCID: https://orcid.org/0000-0001-7198-1625)
- Hugo Sax (ORCID: https://orcid.org/0000-0002-1532-2198)
- Walter Zingg (ORCID: https://orcid.org/0009-0003-7438-1213)
- Danielle Vuichard‐Gysin (ORCID: https://orcid.org/0000-0002-1115-4035)
- Matthias Schlegel (ORCID: https://orcid.org/0000-0003-2847-4956)
- Carlo Balmelli (ORCID: https://orcid.org/0000-0003-0246-2498)
- Holly Jackson (ORCID: https://orcid.org/0000-0003-0646-6437)
- Stephan Harbarth (ORCID: https://orcid.org/0000-0002-3551-1025)
- Aline Wolfensberger (ORCID: https://orcid.org/0000-0001-9028-0007)
- Delphine Berthod
- Nicolas Troillet
- Sarah Tschudin‐Sutter (ORCID: https://orcid.org/0000-0003-4875-5368)
- Andreas F. Widmer (ORCID: https://orcid.org/0000-0002-7661-5824)
- Rami Sommerstein
- Selina Largiadèr
- Niccolò Buetti (ORCID: https://orcid.org/0000-0002-8096-1834)
- Philipp Jent (ORCID: https://orcid.org/0000-0002-1838-9208)
- Alexander Schweiger
- Christelle Perdrieu
Institutions
- University of Bern (CH)
- University of Lucerne (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Swiss Paediatric Oncology Group (CH)
- University Hospital of Geneva (CH)
- Hôpital du Valais (CH)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.40809
- Citations
- 1
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 2.01