Deconvolution of haematological cancer methylation patterns reveals a predominantly non-disease related proliferation signal and uncovers true disease associated methylation changes
This approach leads to a clearer understanding of the role of altered DNA methylation in haematological cancer, facilitates identification of cancer-relevant DNA methylation targeted genes and novel therapeutic targets.
Authors
- Gordon Strathdee (ORCID: https://orcid.org/0000-0001-9681-8429)
- H. Lalchungnunga (ORCID: https://orcid.org/0000-0003-2718-6223)
- Hande Atasoy
- Chris M. Bacon (ORCID: https://orcid.org/0000-0002-8268-2812)
- Ed C. Schwalbe (ORCID: https://orcid.org/0000-0002-1190-9469)
Institutions
- Northumbria University (GB)
- Necmettin Erbakan University (TR)
- National Cancer Institute (US)
- University of Newcastle Australia (AU)
- Newcastle University (GB)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1038/s41416-025-03239-3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kidscan Children's Cancer Research