Spike–fast activity interplay: A gateway to seizure
Our findings support a dynamic, frequency-specific evolution from interictal Sp-HFOs to ictal HFA, suggesting that seizure onset is preceded by a gradual preparatory phase rather than an abrupt transformation. The progressive nature and spectral continuity of Sp-HFOs may reflect increasing neuronal synchrony, providing potential early biomarkers for seizure prediction and improved localization of the EZ.
Authors
- Patrick Chauvel (ORCID: https://orcid.org/0000-0003-2161-6077)
- Thandar Aung (ORCID: https://orcid.org/0000-0002-6770-9642)
- Aude Jegou (ORCID: https://orcid.org/0000-0002-4253-4284)
Institutions
- Cleveland Clinic (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1111/epi.18703
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91