Development of high-titer polyclonal antisera targeting a local bovine viral diarrhea virus-1a strain: A preliminary study from Indonesia

This preliminary study successfully generated high-titer polyclonal antisera against a local Indonesian BVDV-1a strain. The antibodies demonstrated robust reactivity and specificity, highlighting their potential utility as foundational reagents for developing regionally relevant diagnostic assays. While limited by a small sample size and pooled sera, these findings represent an important first step toward establishing locally adapted immunodiagnostic resources for BVDV. The development of local diagnostic tools not only strengthens veterinary disease surveillance but also safeguards livestock-dependent livelihoods, enhances food security, and reduces reliance on imported kits. Improved BVDV control in cattle contributes to One Health by minimizing economic losses, ensuring the safety of animal-derived food products, and reducing the risk of viral persistence in mixed livestock populations.