Effect of melatonin on the osteogenic differentiation of periodontal ligament stem cells: in vitro study
Melatonin is biocompatible and dose-dependently stimulates hPDLSC viability. Melatonin concentrations of 20 and 50 µM were most effective for osteogenic differentiation of hPDLSCs. Our results show that melatonin directly accelerated the differentiation of human periodontal stem cells into osteoblasts and might be used as a pharmaceutical to promote bone regeneration.
Authors
- Razan Yasser Alauti
- Razan Alaqeely (ORCID: https://orcid.org/0000-0001-6461-4552)
- Areej H. Mukhtar
Institutions
- King Saud University (SA)
- Riyadh Elm University (SA)
- Centro de Implantología Cirugía Oral y Maxilofacial (ES)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12903-025-07209-2
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University
- College of Dentistry, King Saud University