Ocean-M: an integrated global-scale multi-omics database for marine microbial diversity, function and ecological interactions
Multi-omics analyses have significantly advanced the understanding of complex marine microbial communities and their interactions. Despite notable progress from recent large-scale ocean meta-analysis efforts, the effective integration and accessibility of these diverse datasets remain challenging. To address this, we introduce Ocean-M (http://om.qnlm.ac), a comprehensive and publicly accessible platform for marine microbial multi-omics data integration, analysis, and visualization. Ocean-M provides a systematic view of 54 083 high-quality metagenome-assembled genomes, including genome assembly statistics, genome clustering, gene annotation, and interactive tools for global-scale taxonomic profiling. The platform also incorporates microbial community networks, host-microbiome interactions, and environmental DNA datasets to support an integrated ecological framework for studying microbial interactions and ecosystem functions. Additionally, Ocean-M enables large-scale mining of ecologically and biotechnologically important genes, with curated catalogs of 151 798 biosynthetic gene clusters, 52 699 antibiotic resistance genes, and millions of carbohydrate-active enzymes and plastic-active enzymes. By combining multi-omics data with environmental metadata, Ocean-M serves as a valuable resource for advancing marine microbial ecology, global biogeography, and functional gene discovery.
Authors
- Jia Lv (ORCID: https://orcid.org/0000-0002-2781-6451)
- Zheng Sun (ORCID: https://orcid.org/0000-0002-8537-8576)
- Xuyuan Duan
- Guangyi Fan (ORCID: https://orcid.org/0000-0001-7365-1590)
- Shuaikang Ma
- Hongkun Zheng (ORCID: https://orcid.org/0000-0002-9426-3615)
- Qing Geng (ORCID: https://orcid.org/0000-0003-4515-5084)
- Fengyi Liu (ORCID: https://orcid.org/0000-0002-9462-701X)
- Shi Huang (ORCID: https://orcid.org/0000-0002-7529-2269)
- Chunyang Li (ORCID: https://orcid.org/0000-0002-1151-4897)
- Guo‐Qing Li (ORCID: https://orcid.org/0000-0002-7449-8433)
- Jing Wang
- Lingling Zhang (ORCID: https://orcid.org/0000-0002-9161-4387)
- Shi Wang (ORCID: https://orcid.org/0000-0002-9571-9864)
- Zhenmin Bao (ORCID: https://orcid.org/0000-0001-6126-0509)
- Yu‐Zhong Zhang (ORCID: https://orcid.org/0000-0002-2017-1005)
- Xiaowen Huang (ORCID: https://orcid.org/0000-0002-2671-1682)
- Yuli Li (ORCID: https://orcid.org/0000-0002-8112-1730)
- Fuyun Liu (ORCID: https://orcid.org/0000-0001-9577-1841)
- Cen Ma
- Jun Wang (ORCID: https://orcid.org/0009-0002-7805-8491)
Institutions
- Qingdao University (CN)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Qingdao Agricultural University (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Biomarker Technologies (China) (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Botswana Geoscience Institute (BW)
- Institute of Microbiology (CN)
- BGI Research (CN)
- Ocean University of China (CN)
- Hainan Tropical Ocean University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1093/nar/gkaf1098
- Citations
- 2
- Primary Topic
- Microbial Community Ecology and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 3.43