shRNA-based PD-1 suppression preserves memory phenotype and function of CD19-targeted CAR-T cell
PD-1 knockdown mitigates tumor-induced T-cell exhaustion and represents a promising strategy to enhance the durability and potency of CAR-T cell therapy in cancer treatment.
Authors
- Jiaxuan Zhao (ORCID: https://orcid.org/0009-0009-9348-0472)
- Yeting Cui (ORCID: https://orcid.org/0009-0000-0590-0006)
- Jiangzhou Shi
- Han Wu (ORCID: https://orcid.org/0000-0002-7418-2930)
- Youyong Wang
- Yixuan Wang (ORCID: https://orcid.org/0000-0003-1612-4502)
- Zhe Sun (ORCID: https://orcid.org/0000-0002-4573-154X)
- Nan Liu (ORCID: https://orcid.org/0009-0003-4309-5513)
- Tongcun Zhang (ORCID: https://orcid.org/0000-0001-9190-2285)
Institutions
- Tianjin University of Science and Technology (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-938
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05