Bioinformatics analysis identifies ULK3 as a novel prognostic and immune-related biomarker in esophageal cancer
<i>ULK3</i>'s mutation profile, expression patterns, prognostic associations, immune correlations and MR results suggest that its elevated expression may reduce EC risk and progression, supporting its potential as a prognostic biomarker. Single-cell and pathway analyses indicate that microautophagy-mediated regulation of tumor proliferation and immunity underlies these effects.
Authors
- Nan Zhao (ORCID: https://orcid.org/0000-0001-9107-2648)
- Kai Cui (ORCID: https://orcid.org/0000-0001-8406-6549)
- Rong Ma (ORCID: https://orcid.org/0009-0009-2060-9853)
- Jinxi He (ORCID: https://orcid.org/0009-0008-7637-8663)
- Yanyang Wang (ORCID: https://orcid.org/0000-0003-3626-8319)
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-989
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00