Molecular dynamics simulation and single-cell and spatial transcriptomics validate immune and prognostic biomarkers in colorectal cancer and construct a clinical prognostic model
This comprehensive study highlights the potential of <i>ULBP2</i>, <i>INHBB</i>, and <i>STC2</i> as promising biomarkers for CRC, emphasizing their roles in regulating tumor progression and immune responses. Future studies should focus on targeted therapeutic strategies that utilize these biomarkers to enhance treatment efficacy and patient prognosis.
Authors
- Yuan Zhou (ORCID: https://orcid.org/0000-0003-1962-2574)
- Songqi Li
- Hongyu Li (ORCID: https://orcid.org/0000-0003-1747-5267)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-6400-6052)
- Qiang Tang (ORCID: https://orcid.org/0000-0003-0239-6072)
- Wang Guo
- Xuanting Chen
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Jinzhou Central Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-918
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00