The role of cancer stem cells in the progression of colorectal cancer and the tumor microenvironment: new perspectives from single-cell RNA sequencing and spatial transcriptomics analyses
This study offers insights into the role of Co-CSS in CRC through ST and gene expression profiling, uncovering novel markers and pathways. It redefines the interplay between Co-CSS and the tumor microenvironment, offering a foundation for future mechanistic studies and therapeutic interventions aimed at targeting Co-CSS to improve CRC treatment.
Authors
- Yang Yang Li (ORCID: https://orcid.org/0000-0003-4153-9558)
- Qiyu Jiang (ORCID: https://orcid.org/0009-0000-6177-7647)
- Xianglin Liu (ORCID: https://orcid.org/0009-0009-4434-8600)
- Wenqiang Liu (ORCID: https://orcid.org/0000-0002-2323-7962)
- Yuting Wu (ORCID: https://orcid.org/0000-0003-3196-5916)
- Hengyu Li (ORCID: https://orcid.org/0000-0002-1007-6493)
- Liqiang Hao
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-586
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00