Comparative microbiome profiling reveals unique signatures in multiple primary lung cancers
For the first time, we demonstrate a potential association between the microbiota and MPLC, revealing distinct microbial profiles in MPLC tumors and their adjacent tissues compared to those in NMPLC. These findings establish a novel diagnostic framework based on microbial biomarkers that enhances early differentiation between MPLC and NMPLC, thereby facilitating timely and subtype-specific therapeutic decisions.
Authors
- Jack Q. Lu (ORCID: https://orcid.org/0009-0007-6454-4014)
- Zheyuan Xu (ORCID: https://orcid.org/0000-0001-9925-7559)
- Yang Wang (ORCID: https://orcid.org/0000-0003-0842-2446)
- Yun Chen (ORCID: https://orcid.org/0000-0002-0906-5367)
- Hao Peng (ORCID: https://orcid.org/0000-0001-6448-3062)
- Shuai Shen (ORCID: https://orcid.org/0000-0001-7229-3832)
- Xiangyun Yan (ORCID: https://orcid.org/0000-0002-9560-5760)
- Q.J. Peng
Institutions
- Kunming University of Science and Technology (CN)
- First People's Hospital of Yunnan Province (CN)
- The First Hospital of Kunming (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-926
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00