Methylation-regulated tumor suppressor gene HOXB4 inhibits human lung adenocarcinoma A549 cell invasion and metastasis through the RAP1 signaling pathway
<i>HOXB4</i> may inhibit the development of LUAD. In this process, hypermethylation of <i>HOXB4</i> predicted early-stage LUAD and was associated with a poorer prognosis. Furthermore, <i>HOXB4</i> regulated the EMT in LUAD cells through the RAP1 pathway, which in turn affected LUAD metastasis and invasion.
Authors
- Lingxiang Zhang (ORCID: https://orcid.org/0000-0003-0529-2252)
- Shu‐Biao Wu (ORCID: https://orcid.org/0000-0002-4040-7388)
- Zhiyuan Xu (ORCID: https://orcid.org/0000-0003-1575-9063)
- Weiyan Peng (ORCID: https://orcid.org/0000-0002-9480-5787)
- Lin Ye (ORCID: https://orcid.org/0000-0002-0303-2409)
- Yamen Ahmed Muad
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-226
- Citations
- 1
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81