Development and validation of nomograms predicting survival in operable breast cancer patients at reproductive age after breast conserving surgery and postoperative radiotherapy based on SEER database
This study establishes validated nomograms that improve survival prediction for young, operable BC patients, identifying high-risk subgroups likely to benefit from neoadjuvant chemotherapy. Conversely, low-risk patients may be spared unnecessary treatment. Prospective validation integrating molecular biomarkers is warranted to refine therapeutic personalization.
Authors
- Zhongzhao Wang (ORCID: https://orcid.org/0009-0009-4841-605X)
- Xuemin Xue (ORCID: https://orcid.org/0000-0002-7842-6883)
- Lixue Xuan (ORCID: https://orcid.org/0000-0002-3550-815X)
- Chenxuan Yang (ORCID: https://orcid.org/0000-0001-9064-9740)
- Changyuan Guo (ORCID: https://orcid.org/0000-0002-0568-9527)
- Huaiyu Yang (ORCID: https://orcid.org/0000-0003-2358-1840)
- Ke Zhang (ORCID: https://orcid.org/0000-0001-5365-3142)
- Lei Guo
- Wei Lu (ORCID: https://orcid.org/0000-0001-8399-8424)
- Sirui Zhu (ORCID: https://orcid.org/0000-0003-0636-3788)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-1059
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00