Prognostic significance of key immune cell functional alterations in clear cell renal cell carcinoma
CD8+ T and NK cells exhibit functional polarization and altered cellular communication indicative of augmented anti-tumor immunity in ccRCC. The immune-cell-derived 10-gene signature provides a reliable prognostic tool and guides personalized therapy.
Authors
- Ke Sun
- Changyi Quan (ORCID: https://orcid.org/0000-0002-3511-5604)
- Shimiao Zhu
- Yin Wu (ORCID: https://orcid.org/0000-0001-8928-0085)
- Wen-jie Niu
- Yantao Zhang (ORCID: https://orcid.org/0000-0002-6661-1133)
- Yanhui Mei
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-971
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00