Comparison of glass‐based and whole‐slide image‐based grade assignment for clear‐cell and papillary renal cell carcinoma: a multi‐cohort, international reproducibility study
WSI-based grading approach for RCC results in divergent grading outcomes, with a trend to over-grading. The interobserver and especially intraobserver agreement present in low to moderate areas for both modalities warrants more standardization and exploring the potential of artificial intelligence for grading objectivization. Institute-specific staining differences might be a confounder for less reproducible RCC grading. We open-source all digital datasets and grades for education and research purposes.
Authors
- Maria Tretiakova (ORCID: https://orcid.org/0000-0002-0819-9638)
- Reinhard Büttner (ORCID: https://orcid.org/0000-0001-8806-4786)
- Alexander Quaas (ORCID: https://orcid.org/0000-0002-9644-2115)
- Tarek A. Bismar (ORCID: https://orcid.org/0000-0002-9190-5088)
- Marie‐Lisa Eich (ORCID: https://orcid.org/0000-0002-8601-4598)
- Henning Reis (ORCID: https://orcid.org/0000-0003-1373-5295)
- Richard Weiten (ORCID: https://orcid.org/0009-0008-6562-5518)
- Joema Felipe Lima
- Wolfgang Hulla (ORCID: https://orcid.org/0000-0001-8189-4621)
- Pia Paffenholz (ORCID: https://orcid.org/0000-0002-8209-7795)
- Yuri Tolkach (ORCID: https://orcid.org/0000-0001-5239-2841)
- George J. Netto (ORCID: https://orcid.org/0000-0003-3915-9134)
- Hoa Pham (ORCID: https://orcid.org/0000-0002-0998-4486)
- Nadine Therese Gaisa (ORCID: https://orcid.org/0000-0002-4762-3964)
- Ibrahim Fahoum (ORCID: https://orcid.org/0000-0002-2811-8647)
- Axel Heidenreich
- Alexey Pryalukhin
- Julian Westerdorf (ORCID: https://orcid.org/0009-0004-5942-3734)
- Nina A Lasnitschka
Institutions
- Goethe University Frankfurt (DE)
- University of Calgary (CA)
- University of Washington (US)
- Tel Aviv Sourasky Medical Center (IL)
- Fachhochschule Wiener Neustadt (AT)
- Humboldt-Universität zu Berlin (DE)
- University Hospital Frankfurt (DE)
- Bạch Mai Hospital (VN)
- University Hospital Cologne (DE)
- University Hospital Ulm (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1111/his.70030
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52