Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model
Accessory-genome GWAS revealed two risk dimensions: acute-virulence programs (HVA) versus mobility functions (LVA) favoring persistence and spread. Because SK measures acute virulence, readouts did not align with high-risk designations. Genomic reports should combine high-risk assignment with accessory-genome and effector profiling to support earlier containment and mechanism-aware, biofilm-focused care.
Authors
- Romário Oliveira de Sales (ORCID: https://orcid.org/0000-0002-4668-6752)
- Patrícia Severino (ORCID: https://orcid.org/0000-0002-6682-9343)
- Marcelo A. Mori (ORCID: https://orcid.org/0000-0001-7112-5263)
- Paula Célia Mariko Koga (ORCID: https://orcid.org/0000-0001-5069-5718)
- Simone Martins de Castro (ORCID: https://orcid.org/0000-0001-6707-9698)
- Laura Leaden
- Alexandra do Rosario Toniolo
- Fernando Gatti de Menezes (ORCID: https://orcid.org/0000-0002-0362-5992)
- Marinês Dalla Valle Martino (ORCID: https://orcid.org/0000-0003-4801-7226)
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Hospital Israelita Albert Einstein (BR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.3389/fmicb.2025.1674635
- Citations
- 1
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.81