A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma
Our findings suggest a potential TLS-based biomarker for HCC prognosis and therapeutic response. This work offers preliminary insights into tumor immune microenvironment (TIME) heterogeneity, which may be modulated by the Treg/Tex balance, and proposes a possible tool for improving patient stratification.
Authors
- J H Liu
- Xiang Yin Kong
- Zi Chun Wang
- Xiaozhong Qiu (ORCID: https://orcid.org/0000-0001-5944-9812)
- Zhen Meng (ORCID: https://orcid.org/0009-0004-2138-1743)
- Xiao Li (ORCID: https://orcid.org/0000-0001-8527-4438)
- Shuangdui Ji (ORCID: https://orcid.org/0009-0006-0924-867X)
- Ming Yu
Institutions
- Union Hospital (HK)
- Union Hospital (CN)
Publication Details
- Journal
- World Journal of Oncology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.14740/wjon2646
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Universidade de Macau
- Department of Finance of Jilin Province