Analysis of the SH3-Domain Kinase Binding Protein 1 Predictive Model for Pancreatic Ductal Adenocarcinoma and CCCTC-Binding Factor Transcriptional Regulatory Study

Via multi-omics integrative analysis, this study systematically elucidated the expression characteristics, spatial distribution, biological functions, and transcriptional regulatory networks of SH3KBP1 in PDAC, confirming its excellent diagnostic/prognostic value and potential as a PDAC molecular target, particularly involving the CTCF regulatory axis. It also provides a key theoretical basis for understanding how SH3KBP1-mediated signaling pathways (regulated by CTCF) drive pancreatic cancer development and progression.