MiR-301a-3p Promotes Triple-Negative Breast Cancer Progression via PTEN Suppression in Tumor Cells and the Microenvironment
MiR-301a-3p drives TNBC progression via exosome-mediated crosstalk with ADSCs, forming a PTEN/PI3K/AKT/VEGFA signaling axis. It represents a promising therapeutic target and novel biomarker with significant clinical value for TNBC treatment.
Authors
- Zheng Fu (ORCID: https://orcid.org/0000-0003-2618-2853)
- Hai Lin (ORCID: https://orcid.org/0000-0002-4713-0414)
- Xi Chen (ORCID: https://orcid.org/0000-0002-9706-3571)
- Bo Fu (ORCID: https://orcid.org/0009-0008-9605-7488)
- Guang Yan Li
- Zhongping Xu (ORCID: https://orcid.org/0000-0003-2559-9091)
- Yao Wang (ORCID: https://orcid.org/0000-0002-4215-6092)
- Jian‐Guo Zhang (ORCID: https://orcid.org/0009-0003-0655-3810)
- Qian Du (ORCID: https://orcid.org/0000-0002-0154-2210)
- W. Liang
- He Cui
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
Institutions
- Harbin Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- World Journal of Oncology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.14740/wjon2670
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province