<scp>GPNMB</scp> immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis
Based on its 100% sensitivity and specificity, GPNMB appears to be a highly valuable immunohistochemical marker for the diagnosis of pulmonary LAM. Besides its diagnostic value, the membrane positivity of GPNMB on LAM cells may predict a response to glembatumumab vedotin, an antibody-drug conjugate targeting GPNMB.
Authors
- Katalin Dezső (ORCID: https://orcid.org/0000-0002-4856-0483)
- Judit Pápay (ORCID: https://orcid.org/0000-0003-2642-2060)
- András Khoór (ORCID: https://orcid.org/0000-0003-0371-0414)
- Levente Kuthi (ORCID: https://orcid.org/0000-0001-9247-6679)
- Ildikó Krencz (ORCID: https://orcid.org/0000-0003-3601-8723)
- Anna Sebestyén (ORCID: https://orcid.org/0000-0001-8814-4794)
- Fatime Szalai (ORCID: https://orcid.org/0009-0002-6129-6143)
Institutions
- Semmelweis University (HU)
- Jacksonville College (US)
- National Institute of Oncology (HU)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1111/his.70026
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Semmelweis Egyetem
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- National Research, Development and Innovation Office
- Division of Human Resource Development