<i>Bifidobacterium infantis</i> modulates intestinal microecology to inhibit the spread of antimicrobial resistance

The global spread of antimicrobial resistance (AMR) has become a significant threat to public health, particularly in children, where the overuse of antibiotics leads to gut microbiota imbalance and increases the risk of horizontal transfer of antibiotic resistance genes (ARGs). This study supplemented mice with <i>Bifidobacterium infantis</i> 15697, which significantly enhanced the synthesis of bile acids, especially tauroursodeoxycholic acid and taurocholic acid, while promoting the growth of probiotics and inhibiting the colonization of antibiotic-resistant bacteria and the spread of ARGs. This finding not only reveals the important role of <i>B. infantis</i> in regulating the gut microbiota and inhibiting the spread of ARGs but also provides a theoretical basis for developing new probiotic intervention strategies. By modulating the gut microbiota and bile acid metabolism, <i>B. infantis</i> has the potential to become an effective means of reducing the spread of AMR. This is of great significance for protecting the gut health of children and adults, reducing the risk of resistant infections, and also provides scientific evidence for the formulation of global public health policies.