PRAME immunohistochemical expression in recurrent/traumatized melanocytic nevi and the pitfall of expression by reactive fibroblasts
This study suggests that PRAME IHC is negative in the melanocytic components of RTMN, distinguishing it from melanoma. However, PRAME positivity in the fibroblastic scar component warrants careful interpretation to avoid diagnostic pitfalls. These findings emphasize the importance of considering the histological context when using PRAME as a diagnostic marker in RTMN.
Authors
- Andrea Ronchi
- Elvira Moscarella (ORCID: https://orcid.org/0000-0001-5160-8997)
- Renato Franco (ORCID: https://orcid.org/0000-0002-8340-3184)
- Emma Carraturo
- Giuseppe D’Abbronzo (ORCID: https://orcid.org/0000-0002-6734-3695)
- Gabriella Brancaccio (ORCID: https://orcid.org/0000-0001-8982-9410)
- Giuseppe Argenziano (ORCID: https://orcid.org/0000-0002-0834-1331)
- Camila Scharf
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Dermatology Practical & Conceptual
- Published
- 2025-10-31
- DOI
- https://doi.org/10.5826/dpc.1504a5564
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00