Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report

This case highlights the necessity for clinicians to maintain high suspicion for SCARs in patients presenting with mucocutaneous symptoms and recent drug exposure-even with commonly used medications not frequently associated with SJS-TEN. The unique presentation involving synchronous ocular, nasal, oral, and genital erosions alongside use of a rare drug combination strengthens the need for early recognition, comprehensive clinical assessment, and cautious prescription practices. Individualized treatment and close monitoring are crucial in preventing mortality and minimizing complications. This case underscores the importance of pharmacovigilance and personalized care in managing drug-induced hypersensitivity reactions, especially in resource-limited or polypharmacy scenarios.

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Publication Details

Journal
Journal of Pharmaceutical Health Care and Sciences
Published
2025-10-31
DOI
https://doi.org/10.1186/s40780-025-00488-5
Primary Topic
Drug-Induced Adverse Reactions
Type
article
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article

Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report

Margi R. Desai, Mrudangsinh Rathod, Harshita Jaiswal, Sakshi Vijayvargi
Journal of Pharmaceutical Health Care and Sciences
Drug-Induced Adverse Reactions
article

Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report

Margi R. Desai, Mrudangsinh Rathod, Harshita Jaiswal, Sakshi Vijayvargi
article en

Abstract

This case highlights the necessity for clinicians to maintain high suspicion for SCARs in patients presenting with mucocutaneous symptoms and recent drug exposure-even with commonly used medications not frequently associated with SJS-TEN. The unique presentation involving synchronous ocular, nasal, oral, and genital erosions alongside use of a rare drug combination strengthens the need for early recognition, comprehensive clinical assessment, and cautious prescription practices. Individualized treatment and close monitoring are crucial in preventing mortality and minimizing complications. This case underscores the importance of pharmacovigilance and personalized care in managing drug-induced hypersensitivity reactions, especially in resource-limited or polypharmacy scenarios.

Journal of Pharmaceutical Health Care and SciencesVol. 11(1)
Gujarat Institute of Development Research (IN), Parul University (IN), Parul University (IN)
Openalex Percentile: Top 64%
Drug-Induced Adverse Reactions
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