Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer’s disease
miR-4284 inhibition confers neuroprotection by modulating APBA1 and JAK/STAT3 signaling, suggesting its potential as a therapeutic target for AD.
Authors
- Byeong C. Kim (ORCID: https://orcid.org/0000-0001-6827-6730)
- Dohee Kim
- Han‐Seong Jeong (ORCID: https://orcid.org/0000-0001-6921-6625)
- Jiyun Choi (ORCID: https://orcid.org/0009-0008-7935-3736)
- Jinsu Hwang (ORCID: https://orcid.org/0009-0008-0672-3601)
- Hyong‐Ho Cho (ORCID: https://orcid.org/0000-0002-1331-4039)
- Sujeong Jang (ORCID: https://orcid.org/0000-0001-8673-7887)
- Eunjae Jang (ORCID: https://orcid.org/0000-0002-0061-9968)
- Geupil Jang (ORCID: https://orcid.org/0000-0002-6231-828X)
Institutions
- Chonnam National University (KR)
- Chonnam National University Hospital (KR)
- Jeonnam Bioindustry Foundation (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s13578-025-01498-4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Chonnam National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea