Vascular Remodelling in COPD: An In Silico Tool to Represent Pulmonary Haemodynamics in Obstructive Lung Disease
This model reproduces clinically measured mPAP and pulmonary vascular resistance values across COPD stages and quantifies how specific degrees of remodelling and pruning drive haemodynamic deterioration. This model provides a tool for hypothesis testing, patient stratification, and evaluation of potential targeted therapies in obstructive lung disease.
Authors
- Alys R. Clark (ORCID: https://orcid.org/0000-0001-5908-2862)
- Merryn H. Tawhai (ORCID: https://orcid.org/0000-0002-3211-6337)
- Kelly Burrowes (ORCID: https://orcid.org/0000-0002-6369-2951)
- Behdad Shaarbaf Ebrahimi (ORCID: https://orcid.org/0000-0001-6254-6226)
- Bryan G. Allen (ORCID: https://orcid.org/0000-0002-4893-7105)
Institutions
- University of Auckland (NZ)
- Auckland University of Technology (NZ)
- Auckland UniServices (New Zealand) (NZ)
- Bioengineering Center (RU)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1007/s10439-025-03891-z
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royal Society Te Apārangi