Of the article: Microbiological assessment of a herbal mouth rinse for treating chronic generalized periodontitis
Periodontal diseases remain highly prevalent across age groups, often aggravated by poor oral hygiene, occlusal anomalies, and defective restorations. This study evaluated the effectiveness of Art-Dentale Expert mouthwash against major periodontopathogens in patients with mild chronic generalized periodontitis (CGP) using PCR diagnostics. Thirty-nine patients with CGP were randomized into a main group (Art-Dentale Expert) and a control group (Chlorhexidine). Gingival pocket samples were collected before treatment and at 7 days, 1 month, and 6 months. Four periodontopathogens (P. gingivalis, T. forsythia, T. denticola, and P. intermedia) were analyzed. The results obtained were processed statistically. Both rinses significantly reduced P. gingivalis and T. forsythia at 7 days, with Chlorhexidine showing a sharper initial decline in P. gingivalis. At 6 months, P. intermedia was completely absent in the Art-Dentale Expert group (p = 0.0209), whereas it persisted in 10% of controls. Art-Dentale Expert demonstrated sustained efficacy, particularly against T. denticola and P. intermedia. These findings support its role as an effective adjunct in periodontal therapy.
Authors
- Svetlana Razumova (ORCID: https://orcid.org/0000-0002-9533-9204)
- Anzhela Brago (ORCID: https://orcid.org/0000-0001-8947-4357)
- А. И. Марахова (ORCID: https://orcid.org/0000-0003-4442-9266)
- Haydar Barakat (ORCID: https://orcid.org/0000-0003-0911-3063)
- S. N. Panov (ORCID: https://orcid.org/0009-0003-1631-6552)
- Екатерина Станиславовна Михайлова (ORCID: https://orcid.org/0000-0002-0835-7253)
- I. V. Koroleva (ORCID: https://orcid.org/0000-0002-7966-5130)
Institutions
- Peoples' Friendship University of Russia (RU)
- St Petersburg University (RU)
- Institute of Experimental Medicine (RU)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1038/s41598-025-22028-9
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- RUDN University