Molecular reflex testing in patients with early metastatic castration-resistant prostate cancer within the PROMPT-study

Molecular tumour testing should preferably be done on metastatic mCRPC tissue. No combination of features could robustly identify druggable genotypes; therefore, reflex molecular characterisation should be routine for every mCRPC patient.

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Publication Details

Journal
British Journal of Cancer
Published
2025-10-31
DOI
https://doi.org/10.1038/s41416-025-03243-7
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Molecular reflex testing in patients with early metastatic castration-resistant prostate cancer within the PROMPT-study

Iris S. H. Kloots, Sofie H. Tolmeijer, Tineke J. Smilde, Marjolijn J. L. Ligtenberg et al.
British Journal of Cancer
Prostate Cancer Treatment and Research
article

Molecular reflex testing in patients with early metastatic castration-resistant prostate cancer within the PROMPT-study

Iris S. H. Kloots, Sofie H. Tolmeijer, Tineke J. Smilde, Marjolijn J. L. Ligtenberg, C. Marleen Kets, Leonie I. Kroeze, Niven Mehra, Sjoerd van Helvert, Joyce M. van Dodewaard, Jurgen J. Fütterer, Peter H. J. Slootbeek, Theo van Voorthuizen, Katrien Grünberg, Minke Smits, Jolique A. van Ipenburg, Haiko J. Bloemendal, Jack A. Schalken, Frederiek Terheggen, Sandra van Wilpe, Inge M. van Oort, James Nagarajah, Winald R. Gerritsen
article en

Abstract

Molecular tumour testing should preferably be done on metastatic mCRPC tissue. No combination of features could robustly identify druggable genotypes; therefore, reflex molecular characterisation should be routine for every mCRPC patient.

British Journal of CancerVol. 134(2)
University Medical Center Groningen (NL), Radboud University Nijmegen (NL), Radboud University Medical Center (NL), Rijnstate Hospital (NL), Meander Medisch Centrum (NL), Jeroen Bosch Ziekenhuis (NL), Bravis Ziekenhuis (NL)
Radboud Universitair Medisch Centrum
Openalex Percentile: Top 54%
Prostate Cancer Treatment and Research
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