Molecular reflex testing in patients with early metastatic castration-resistant prostate cancer within the PROMPT-study
Molecular tumour testing should preferably be done on metastatic mCRPC tissue. No combination of features could robustly identify druggable genotypes; therefore, reflex molecular characterisation should be routine for every mCRPC patient.
Authors
- Iris S. H. Kloots (ORCID: https://orcid.org/0000-0001-9181-1359)
- Sofie H. Tolmeijer (ORCID: https://orcid.org/0000-0003-4066-885X)
- Tineke J. Smilde (ORCID: https://orcid.org/0000-0002-4196-3765)
- Marjolijn J. L. Ligtenberg (ORCID: https://orcid.org/0000-0003-1290-1474)
- C. Marleen Kets (ORCID: https://orcid.org/0000-0003-4158-763X)
- Leonie I. Kroeze (ORCID: https://orcid.org/0000-0002-2666-1742)
- Niven Mehra (ORCID: https://orcid.org/0000-0002-4794-1831)
- Sjoerd van Helvert (ORCID: https://orcid.org/0000-0002-4958-9819)
- Joyce M. van Dodewaard
- Jurgen J. Fütterer (ORCID: https://orcid.org/0000-0001-6800-2879)
- Peter H. J. Slootbeek (ORCID: https://orcid.org/0000-0002-5635-919X)
- Theo van Voorthuizen (ORCID: https://orcid.org/0000-0002-2844-4338)
- Katrien Grünberg (ORCID: https://orcid.org/0000-0003-1164-4365)
- Minke Smits (ORCID: https://orcid.org/0000-0003-1360-7285)
- Jolique A. van Ipenburg (ORCID: https://orcid.org/0000-0001-5029-1983)
- Haiko J. Bloemendal (ORCID: https://orcid.org/0000-0002-8902-4337)
- Jack A. Schalken (ORCID: https://orcid.org/0000-0001-8274-7797)
- Frederiek Terheggen
- Sandra van Wilpe (ORCID: https://orcid.org/0000-0002-0164-7549)
- Inge M. van Oort (ORCID: https://orcid.org/0000-0002-8002-1869)
- James Nagarajah (ORCID: https://orcid.org/0000-0002-3555-0809)
- Winald R. Gerritsen
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Rijnstate Hospital (NL)
- Meander Medisch Centrum (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Bravis Ziekenhuis (NL)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1038/s41416-025-03243-7
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universitair Medisch Centrum