Pyruvate Dehydrogenase Complex Stimulation With Dichloroacetate May Improve Septic Cardiac Dysfunction
Our findings revealed that sepsis decreased PDH activity in cardiac tissue. Rebalancing PDH activity with DCA improved cardiac performance after CLP. While imaging mass spectrometry identified changes in itaconate concentration and enabled detection of tricarboxylic acid cycle metabolites, further investigation is necessary to determine whether DCA is an effective therapeutic agent for septic cardiomyopathy.
Authors
- Boone M. Prentice (ORCID: https://orcid.org/0000-0002-1927-9457)
- Anderson O. Cox (ORCID: https://orcid.org/0000-0001-5491-1019)
- Lane M. Smith (ORCID: https://orcid.org/0000-0002-7418-3351)
- Barbara K. Yoza (ORCID: https://orcid.org/0000-0002-0059-5783)
- David Long
- Charles E. McCall (ORCID: https://orcid.org/0000-0001-6176-8177)
- Manal Zabalawi
- Peter W. Stacpoole (ORCID: https://orcid.org/0000-0003-0680-5881)
- Y. T. Lin
- Chelsey S. Mertens
Institutions
- University of Florida (US)
- Wake Forest University (US)
- Florida College (US)
Publication Details
- Journal
- Shock
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1097/shk.0000000000002642
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00