Effectiveness of rapid urease, serum antibody, and histopathological detection of helicobacter pylori infection in children

This was an original study, aimed to explore the efficacy of rapid urease, serum antibody and histopathological detection of Helicobacter pylori (Hp) infection in children. One hundred and forty (140)children admitted to Liaoning Cancer Hospital & Institute due to gastrointestinal symptoms who underwent electronic gastroscopy from June 2020 to June 2022 were included. Among the 140 children, 72 were positive for Hp infection by rapid urease, 71 with serum antibody, and 67 with histopathology. The specificities of Hp infection detected by the three methods - rapid urease, serum antibody and histology were 88.7%, 90.6% and 91.7%, respectively. We conclude that the combination of three detection methods of rapid urease, serum antibody and histopathology can improve the sensitivity, specificity, and the accuracy of Hp detection.