A meta-analysis and systematic review of the effect of dinoprostone in full term pregnancy labor induction

This meta-analysis comprehensively evaluates Dinoprostone's efficacy and safety in full-term labor induction through systematic review of 11 studies from Cochrane, PubMed, Medline, Embase, WeiPu, and Google Scholar databases. The search strategy included key terms such as dinoprostone, prostaglandin E2, cervical ripening, and labor induction, applied across both Chinese and English literature. The analysis demonstrated significant advantages in vaginal delivery rates within 24 hours (OR=0.66, 95%CI:0.55-0.81, P<0.0001) with acceptable heterogeneity (I²=33%, P=0.14). Neonatal outcomes favored Dinoprostone, showing reduced incidence of 1-minute Apgar scores <7 (OR=0.64, 95%CI:0.48-0.84, P=0.002). Comparative analysis revealed Dinoprostone's longer medication to-delivery interval but superior safety profile versus Misoprostol, particularly in 5 min Apgar scores. These findings provide robust evidence for clinical decision-making regarding prostaglandin-based labor induction protocols.