C1QBP Drives M2 Macrophage Polarization Via TRAF2-CCL2 to Promote Oral Squamous Cell Carcinoma Progression
These findings suggest that C1QBP modulates the polarization of macrophages toward the M2 phenotype via the TRAF2-CCL2 signaling axis, thus contributing to OSCC malignancy progression. Consequently, targeting C1QBP to regulate M2 macrophage polarization may provide a promising therapeutic avenue for OSCC management.
Authors
- Kai Kang (ORCID: https://orcid.org/0000-0002-9802-2309)
- Xiyuan Qin
- Shoushan Bu (ORCID: https://orcid.org/0000-0001-6831-5904)
- Bowen Zhu
- Yujie Shi (ORCID: https://orcid.org/0000-0002-4772-8475)
Institutions
- Stomatology Hospital (CN)
- Southern Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1016/j.identj.2025.103938
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80