Giant lipoma in the deep palmar compartment: surgical challenges

Lipomas are common benign tumors, but their occurrence in the deep palmar space is rare due to anatomical constraints. We report the case of a 30-year-old male with a 2-year history of a progressively enlarging, painless swelling in the right palm, leading to impaired grip function. Imaging revealed a well-defined fatty lesion in the deep palmar space closely associated with the flexor tendons. The mass was excised completely with preservation of neurovascular and tendinous structures. Histopathology confirmed a lipoma. The patient recovered full hand function within four weeks. This case highlights the need to consider deep palmar lipomas in the differential diagnosis of chronic hand swellings and demonstrates that appropriate imaging and meticulous surgical excision can lead to excellent outcomes.