Direct utilization of hydrogen sulfide gas for aryl thiol synthesis <i>via</i> adaptive dynamic homogeneous catalysis in a flow system
We present our initial results on C(sp<sup>2</sup>)-S cross-couplings employing the adaptive dynamic homogeneous catalysis (AD-HoC) strategy in combination with H<sub>2</sub>S gas as an economically viable reagent for aryl thiol synthesis. To ensure the safe and efficient use of toxic H<sub>2</sub>S gas, process development was carried out in a commercially available continuous flow photoreactor under visible-light irradiation, with a simple Brønsted acid playing a key role in promoting the reaction.
Authors
- Hiroshi Kitamura (ORCID: https://orcid.org/0000-0001-9643-3211)
- Sándor B. Ötvös (ORCID: https://orcid.org/0000-0001-6673-1744)
- Indrajit Ghosh (ORCID: https://orcid.org/0000-0002-5127-2271)
- C. Oliver Kappe (ORCID: https://orcid.org/0000-0003-2983-6007)
- Burkhard Koenig (ORCID: https://orcid.org/0000-0002-6131-4850)
- Maksim Nikitin (ORCID: https://orcid.org/0000-0002-4519-8669)
Institutions
- VSB - Technical University of Ostrava (CZ)
- University of Graz (AT)
- Nawi Graz (AT)
- Research Center Pharmaceutical Engineering (Austria) (AT)
- University of Regensburg (DE)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04825g
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00