Evaluation of a diagnostic metagenomic sequencing assay: Virus detection sensitivity and background nucleic acids in three different sample materials
Our results highlight the need to consider sample-type specific characteristics in efforts to improve the sensitivity of metagenomic assays e.g. via host depletion protocols.
Authors
- Shambhu G. Aralaguppe (ORCID: https://orcid.org/0000-0001-7398-8927)
- Dan Sun (ORCID: https://orcid.org/0000-0003-2147-9308)
- Niklas K. Björkström (ORCID: https://orcid.org/0000-0002-0967-076X)
- Tobias Allander
- Sandra Broddesson (ORCID: https://orcid.org/0009-0009-3198-6400)
- Jan Albert (ORCID: https://orcid.org/0000-0001-9020-0521)
- Sofia Stamouli (ORCID: https://orcid.org/0009-0006-0893-3771)
- Amir Mahani
- Tanja Normark
- Lili Li (ORCID: https://orcid.org/0000-0002-6059-4192)
- Valtteri Wirta (ORCID: https://orcid.org/0000-0003-3811-5439)
- Martin Ekman
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of Clinical Virology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1016/j.jcv.2025.105882
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43