Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study
SCZ-FH showed associations with broad psychopathology, while SCZ-PRS was associated with cognition and specific symptoms in European youth. Findings highlight their complementary role in SCZ risk assessment and the need to improve PRS utility across ancestries.
Authors
- Jennifer K. Forsyth (ORCID: https://orcid.org/0000-0002-8786-0024)
- Tim B. Bigdeli (ORCID: https://orcid.org/0000-0003-2215-5946)
- Mahnoor Hyat (ORCID: https://orcid.org/0000-0001-8039-4860)
- Alison E. Fohner (ORCID: https://orcid.org/0000-0003-4231-3331)
- Toni Boltz (ORCID: https://orcid.org/0000-0003-0226-7924)
- Matthew P. Conomos (ORCID: https://orcid.org/0000-0001-9744-0851)
- Katherine T. Foster (ORCID: https://orcid.org/0000-0002-3561-6687)
- Jinhan Zhu
- Dylan Hughes (ORCID: https://orcid.org/0009-0003-3759-2417)
Institutions
- Broad Institute (US)
- State University of New York (US)
- University of California, Los Angeles (US)
- SUNY Downstate Health Sciences University (US)
- University of Washington (US)
- VA NY Harbor Healthcare System (US)
- University of California System (US)
- Cancer Research And Biostatistics (US)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725102304
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- University of Washington
- National Institute of Mental Health