Safety of Valproic Acid Use in Pregnant Women: A Systematic Review and Meta‐Analysis
VPA monotherapy significantly increases teratogenic risk, especially for neural tube defects and cleft lip/palate. Newer AEDs with lower risk profiles are preferred for epilepsy treatment during pregnancy. If VPA use is unavoidable, low doses and blood concentration monitoring are recommended to mitigate risk.
Authors
- Pengqiang Du (ORCID: https://orcid.org/0000-0001-6943-485X)
- Xinying Yang (ORCID: https://orcid.org/0000-0002-5132-2195)
- Xingang Li (ORCID: https://orcid.org/0000-0001-6726-9571)
- Yiqi Sun
- Taoran Li (ORCID: https://orcid.org/0000-0002-0451-2850)
- Zixin Hua
Institutions
- Capital Medical University (CN)
- Zhengzhou Central Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Journal of obstetrics and gynaecology research
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1111/jog.70121
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00