Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy
These findings might support the investigation of immunotherapy in patients with mCRC pretreated with EGFR inhibitors with high mutational load.
Authors
- Pierosandro Tagliaferri (ORCID: https://orcid.org/0000-0002-1535-2477)
- Tiziana Pia Latiano (ORCID: https://orcid.org/0000-0001-9730-5668)
- Nicola Normanno (ORCID: https://orcid.org/0000-0002-7158-2605)
- L. Antonuzzo
- Giuseppe Curigliano (ORCID: https://orcid.org/0000-0003-1781-2518)
- Stefania Napolitano (ORCID: https://orcid.org/0000-0003-3504-8349)
- Erika Martinelli (ORCID: https://orcid.org/0000-0002-0291-475X)
- Roberto Bordonaro (ORCID: https://orcid.org/0000-0001-5005-0880)
- Ferdinando De Vita (ORCID: https://orcid.org/0000-0002-7654-7470)
- Claudia Cardone (ORCID: https://orcid.org/0000-0003-4502-1932)
- F. Pietrantonio
- M Bosco
- Alberto Zaniboni
- C Nisi
- Salvatore Pisconti (ORCID: https://orcid.org/0000-0002-1658-523X)
- Giuseppe Santabarbara
- Rossana Berardi (ORCID: https://orcid.org/0000-0002-9529-2960)
- Emiliano Tamburini (ORCID: https://orcid.org/0000-0003-4619-7091)
- Nicola Fazio (ORCID: https://orcid.org/0000-0001-6869-0704)
- Teresa Troiani (ORCID: https://orcid.org/0000-0002-0646-4901)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Andrea Sartore‐Bianchi (ORCID: https://orcid.org/0000-0003-0780-0409)
- Salvatore Siena (ORCID: https://orcid.org/0000-0002-2681-2846)
- Elena Ongaro (ORCID: https://orcid.org/0000-0003-0548-7092)
- Mario Scartozzi (ORCID: https://orcid.org/0000-0001-5977-5546)
- Alessia Russo (ORCID: https://orcid.org/0000-0002-5494-2218)
- A. Febbraro
- Carmine Pinto (ORCID: https://orcid.org/0000-0002-3159-5268)
- Alfonso De Stefano (ORCID: https://orcid.org/0000-0003-2107-1177)
- Valentina De Falco (ORCID: https://orcid.org/0000-0002-8972-7921)
- Evaristo Maiello (ORCID: https://orcid.org/0000-0003-3890-3435)
- Davide Ciardiello (ORCID: https://orcid.org/0000-0003-1826-0305)
- Giampaolo Tortora (ORCID: https://orcid.org/0000-0002-1378-4962)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Fortunato Ciardiello (ORCID: https://orcid.org/0000-0002-3369-4841)
- Carlo Garufi
- Luca Boscolo Bielo (ORCID: https://orcid.org/0000-0003-1026-3923)
- Livio Blasi (ORCID: https://orcid.org/0000-0001-7150-1302)
- Giulia Martini (ORCID: https://orcid.org/0000-0003-4093-2681)
- Claudio Lotesoriere (ORCID: https://orcid.org/0000-0002-7999-9739)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Maria Giulia Zampino (ORCID: https://orcid.org/0000-0001-5142-1778)
- Antonio Avallone (ORCID: https://orcid.org/0000-0001-6188-5664)
- Luigi Pio Guerrera (ORCID: https://orcid.org/0000-0002-1475-3252)
- Marco Messina (ORCID: https://orcid.org/0009-0009-8408-8217)
- N. Salmistraro
- A Iacovucci
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- Marche Polytechnic University (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Casa Sollievo della Sofferenza (IT)
- Villa Maria Hospital (UG)
- Agostino Gemelli University Polyclinic (IT)
- Magna Graecia University (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Ospedale di Cattinara (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale Garibaldi (IT)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda Ospedaliero-Universitaria Cagliari (IT)
- Centro di Riferimento Oncologico (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Azienda di Rilievo Nazionale ed Alta Specializzazione (IT)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- University of the Sacred Heart (JP)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Florence (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105877
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00