Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy

These findings might support the investigation of immunotherapy in patients with mCRC pretreated with EGFR inhibitors with high mutational load.

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Publication Details

Journal
ESMO Open
Published
2025-10-28
DOI
https://doi.org/10.1016/j.esmoop.2025.105877
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
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article

Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy

Pierosandro Tagliaferri, Tiziana Pia Latiano, Nicola Normanno, L. Antonuzzo et al.
ESMO Open
Colorectal Cancer Treatments and Studies
article

Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy

Pierosandro Tagliaferri, Tiziana Pia Latiano, Nicola Normanno, L. Antonuzzo, Giuseppe Curigliano, Stefania Napolitano, Erika Martinelli, Roberto Bordonaro, Ferdinando De Vita, Claudia Cardone, F. Pietrantonio, M Bosco, Alberto Zaniboni, C Nisi, Salvatore Pisconti, Giuseppe Santabarbara, Rossana Berardi, Emiliano Tamburini, Nicola Fazio, Teresa Troiani, Paola Parente, Andrea Sartore‐Bianchi, Salvatore Siena, Elena Ongaro, Mario Scartozzi, Alessia Russo, A. Febbraro, Carmine Pinto, Alfonso De Stefano, Valentina De Falco, Evaristo Maiello, Davide Ciardiello, Giampaolo Tortora, Sara Lonardi, Fortunato Ciardiello, Carlo Garufi, Luca Boscolo Bielo, Livio Blasi, Giulia Martini, Claudio Lotesoriere, Chiara Cremolini, Maria Giulia Zampino, Antonio Avallone, Luigi Pio Guerrera, Marco Messina, N. Salmistraro, A Iacovucci
article en

Abstract

These findings might support the investigation of immunotherapy in patients with mCRC pretreated with EGFR inhibitors with high mutational load.

ESMO OpenVol. 10(11)
Università Cattolica del Sacro Cuore (IT), University of Pisa (IT), Marche Polytechnic University (IT), University of Campania "Luigi Vanvitelli" (IT), Casa Sollievo della Sofferenza (IT), Villa Maria Hospital (UG), Agostino Gemelli University Polyclinic (IT), Magna Graecia University (IT), Azienda Sanitaria Unità Locale di Reggio Emilia (IT), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Azienda Ospedaliera San Camillo-Forlanini (IT), Ospedale di Cattinara (IT), Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT), Ospedale Garibaldi (IT), Istituto Oncologico Veneto (IT), Azienda Ospedaliera S.Giuseppe Moscati (IT), Azienda Ospedaliero-Universitaria Careggi (IT), Azienda Ospedaliero-Universitaria Cagliari (IT), Centro di Riferimento Oncologico (IT), Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT), Azienda di Rilievo Nazionale ed Alta Specializzazione (IT), Fondazione Poliambulanza Istituto Ospedaliero (IT), University of the Sacred Heart (JP), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Gastroenterology Hospital "Saverio de Bellis" (IT), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), University of Florence (IT), European Institute of Oncology (IT)
Openalex Percentile: Top 57%
Colorectal Cancer Treatments and Studies
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