Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol‐Induced Heart Failure
In this model, heart dysfunction was initially evidenced by cardiac dilation. At 4 days of isoproterenol treatment, calcium levels and contractility decreased. Subsequently, decompensation coincided with a collapse in mitochondrial ATP production.
Authors
- Juan Llopis (ORCID: https://orcid.org/0000-0002-9460-0642)
- Manuel Vicente (ORCID: https://orcid.org/0000-0002-9464-918X)
- A Martinez-Sielva (ORCID: https://orcid.org/0000-0002-1337-308X)
- Joaquı́n Jordán (ORCID: https://orcid.org/0000-0002-6809-3384)
- Jussep Salgado‐Almario (ORCID: https://orcid.org/0000-0002-7421-6168)
- Beatriz Domingo (ORCID: https://orcid.org/0000-0001-9430-4803)
- Aarón García-Blázquez (ORCID: https://orcid.org/0000-0002-1127-9313)
Institutions
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1111/apha.70128
- Citations
- 1
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Universidad de Castilla-La Mancha
- Université de Montpellier
- European Regional Development Fund