Sexual Dysfunctions Associated with Proton Pump Inhibitors: Insights from VigiBase, the World Health Organization Pharmacovigilance Database
Findings of this study suggest the presence of safety signals of PPI-induced sexual dysfunctions, such as erectile dysfunction, genital discomfort and oestrogen deficiency. However, further observational studies are required to validate and further characterise these potential safety signals.
Authors
- Francesco Ciccimarra (ORCID: https://orcid.org/0009-0009-7321-0950)
- Maria Cristina De Martino (ORCID: https://orcid.org/0000-0003-3354-009X)
- Elisa Giannetta (ORCID: https://orcid.org/0000-0003-3614-6151)
- Luca L’Abbate (ORCID: https://orcid.org/0000-0003-0232-6402)
- Jordi Mestres (ORCID: https://orcid.org/0000-0002-5202-4501)
- Marco Tuccori (ORCID: https://orcid.org/0000-0002-7979-8486)
- Gianluca Trifirò (ORCID: https://orcid.org/0000-0003-1147-7296)
- Emmanuele Angelo Jannini (ORCID: https://orcid.org/0000-0002-5874-039X)
- Fabio Scapini
- Salvatore Crisafulli
Institutions
- University of Rome Tor Vergata (IT)
- University of Verona (IT)
- Universitat de Girona (ES)
- Thrombotargets (Spain) (ES)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Drug Safety
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1007/s40264-025-01626-6
- Citations
- 1
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Università degli Studi di Verona